Every so often, Goonswarm members hold an event called: 'Burn Jita'. Basically what happens is that the Goons effectively blockade the Jita system and go out of their way to gank anyone in a industrial, mining barge, exhumers, transports, freighters and jump freighters. As we all know, Jita is the largest trade hub in New Eden and as such, there are masses of people moving in and out of Jita on a minute by minute basis. Jita is normally a dangerous place, even though it is in High Sec. Gankers are always trying to pop a hapless capsuleer. What is even more interesting is that the Goon's declare a 'Bun' event well in advance. It never ceases to amaze me the absolute slew of killmails on industrial ships and shiny PVE fit hulls. The forewarning and Jita's typically chaotic daily activity is not enough to keep people away.
You can see a great post by Jester, where he gives a disturbing tally of the losses. I suggest you go check it out. Burn Jita 3.0 Wrap-up
I just wanted to make one more point. If a 'Burn' event is announced, be smart and find another activity or another trade hub for a while. Don't autopilot and pay attention and as always, fly safe-ish.